Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive dementia affecting cognition, behavior and functional status of a person. Recent studies suggest that free radicals play a key role in the pathology of AD by inducing lipid peroxidation and neuronal death. Linseed oil is a potent antioxidant and is believed to have beneficial effects. However, no study has been reported on neuroprotective effect of linseed oil on aluminum chloride induced Alzheimer’s disease in rats. Male wistar rats weighing (150-200 g) were divided into 5 groups of 6 animals each. Group 1 (normal control): Received distilled water orally for 30 days. Group 2 (disease control): Received aluminium chloride (25 mg/kg p.o) for 30 days to induce experimental Alzheimer’s disease. Group 3 (standard group): Received aluminium chloride + standard donepezil (10 mg/kg p.o) for 30 days. Group 4 (disease treated group): Received aluminium chloride + low dose of linseed oil (1 ml/kg p.o) daily for 30 days. Group 5 (disease treated): Received aluminium chloride + high dose of linseed oil (2 ml/kg p.o) daily for 30 days. Behavioral tests were conducted at every week such as open field test, elevated plus maze test, T-maze test, modified elevated plus maze test and rotarod test. On 31st day, the animals were sacrificed by giving thiopental sodium. The brain was isolated for biochemical estimations such as acetyl cholinesterase, super oxide dismutase (SOD), malondialdehyde (MDA), reduced glutathione (GSH), nitrate level, total proteins and histopathology. The present study suggests that, linseed oil may show beneficial effects in treating Alzheimer’s disease. This activity may be due to its antioxidant and anticholinesterase effects. The neuroprotective effect of linseed oil on aluminium chloride induced AD might be associated with its AchE activity and free radical scavenging activity.
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